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Common PCT cycles after using Primobolan Depot with other steroids lasts between three to four weeks with the use of Clomid at 50mg per day. There is no difference observed in the frequency of side effects when using Primobolan Depot with other steroids after a two year exposure [17-20].ClotrimazoleAn extended-release formulation of clomiphene citrate has been successfully shown to be effective in the prevention of vaginal dryness. These formulations are currently being studied in clinical settings, including at-home use [7-9]. A study by Cresswell et al evaluated the efficacy of a three treatment regimen of clomiphene and tetracycline to treat vaginitis and chronic pelvic pain for 12 hours on an outpatient basis using a patient population of adult women. There were no significant differences observed in the rates of pain relief at the end of the study (95% confidence interval 0.3 to 7.4) compared to the group of women who were told to remain home and take the oral tablet .Clinical trials of oral tetracycline for the treatment of pelvic pain and vaginitis have been conducted in a number of countries to date. The results of these studies are inconsistent, but they suggest that oral tetracycline is associated with a decrease in vaginal dryness compared to placebo, which is consistent with the findings of studies showing no significant differences between oral clomiphene and Tetracycline [19-22]. Thus, the safety profile of clomiphene and tricycline combined formulations is supported by the clinical trials currently available. The use of tricyclines in women is contraindicated because of the risk of gastrointestinal and hepatic reactions from the metabolites and other toxic effects, including death of the fetus which occurs with administration of these medications [43,44].Gonal SteroidsOral administration of gonal steroids for vaginal dryness may increase the risk of bleeding and pelvic inflammatory disease. A major issue with the use of gonal steroids for vaginal dryness is the potential for serious adverse effects. Although in a review of four clinical trials of gonal estrogens in women with symptomatic vaginal dryness, the risk of uterine fibroids or infertility and intrauterine infection was associated with gonal steroids more often than not, these results were not observed in a separate report . A study of three gonal estrogen trials also revealed that uterine fibroids or infertility were more commonly induced in the gonal-estrogen group compared to the control group .Related Article: